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Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
Y Feng, Y **ong, T Qiao, X Li, L Jia, Y Han - Cancer medicine, 2018 - Wiley Online Library
Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …
MYC, metabolism, and cancer
The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …
Equivariant 3D-conditional diffusion model for molecular linker design
Fragment-based drug discovery has been an effective paradigm in early-stage drug
development. An open challenge in this area is designing linkers between disconnected …
development. An open challenge in this area is designing linkers between disconnected …
Role of mitochondrial membrane potential and lactate dehydrogenase a in apoptosis
Apoptosis is a programmed cell death that occurs due to the production of several catabolic
enzymes. During this process, several morphological and biochemical changes occur in …
enzymes. During this process, several morphological and biochemical changes occur in …
Targeting lactate dehydrogenase-a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells
The lactate dehydrogenase-A (LDH-A) enzyme catalyzes the interconversion of pyruvate
and lactate, is upregulated in human cancers, and is associated with aggressive tumor …
and lactate, is upregulated in human cancers, and is associated with aggressive tumor …
The biochemical and clinical perspectives of lactate dehydrogenase: an enzyme of active metabolism
Background: Lactate dehydrogenase (LDH) is a group of oxidoreductase isoenzymes
catalyzing the reversible reaction between pyruvate and lactate. The five isoforms of this …
catalyzing the reversible reaction between pyruvate and lactate. The five isoforms of this …
Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer
K Augoff, A Hryniewicz-Jankowska, R Tabola - Cancer letters, 2015 - Elsevier
A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic
glycolysis with lactate production coupled with a higher uptake of glucose as the main …
glycolysis with lactate production coupled with a higher uptake of glucose as the main …
Fragment-based drug discovery using NMR spectroscopy
MJ Harner, AO Frank, SW Fesik - Journal of biomolecular NMR, 2013 - Springer
Nuclear magnetic resonance (NMR) spectroscopy has evolved into a powerful tool for
fragment-based drug discovery over the last two decades. While NMR has been traditionally …
fragment-based drug discovery over the last two decades. While NMR has been traditionally …
Fragment linking strategies for structure-based drug design
Fragment-based drug discovery is a strategy widely used in both academia and
pharmaceutical companies to generate small-molecule protein inhibitors and drug …
pharmaceutical companies to generate small-molecule protein inhibitors and drug …
Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells
Background Most normal cells in the presence of oxygen utilize glucose for mitochondrial
oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in …
oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in …