Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

A high level of homocysteine (Hcy) is associated with oxidative/ER stress, apoptosis, and
impairment of angiogenesis, whereas hydrogen sulfide (H2S) has been found to reverse this …

Puerarin has shown unique pharmacological effects on myocardial ischemia (MI). Changing
the crystal form is an effective approach to improve the cardioprotective effects of puerarin …

Abstract 'Cardiosomes'(exosomes from cardiomyocytes) have recently emerged as
nanovesicles (30–100 nm) released in the cardiosphere by myocytes and cardiac progenitor …

Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated
with a number of diseases, including cardiovascular disease, dementia, neural tube defects …

Chronic inflammatory diseases, including allergies and asthma, are the result of complex
gene-environment interactions. One of the most challenging questions in this regard relates …

Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism lead to
hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of …

Mitochondrial dysfunction underlines a multitude of pathologies; however, studies are
scarce that rescue the mitochondria for cellular resuscitation. Exploration into the protective …

Abstract DNA methyltransferase 1 (DNMT1) shows close link with heart disease. This study
aimed to define the role DNMT1 plays in heart failure and determine the underlying …

The bidirectional cross talk between nuclear and mitochondrial DNA is essential for cellular
homeostasis and proper functioning. Mitochondria depend on nuclear contribution for much …