RNA modifications in physiology and disease: towards clinical applications

S Delaunay, M Helm, M Frye - Nature Reviews Genetics, 2024 - nature.com
The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

P Nombela, B Miguel-López, S Blanco - Molecular cancer, 2021 - Springer
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

RNA modification: mechanisms and therapeutic targets

L Qiu, Q **g, Y Li, J Han - Molecular biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

Small RNA modifications: regulatory molecules and potential applications

Q **ong, Y Zhang - Journal of hematology & oncology, 2023 - Springer
Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …

Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

KE Bohnsack, C Höbartner, MT Bohnsack - Genes, 2019 - mdpi.com
5-methylcytosine (m5C) is an abundant RNA modification that's presence is reported in a
wide variety of RNA species, including cytoplasmic and mitochondrial ribosomal RNAs …

RNA modifications regulating cell fate in cancer

S Delaunay, M Frye - Nature cell biology, 2019 - nature.com
The deposition of chemical modifications into RNA is a crucial regulator of temporal and
spatial gene expression programs during development. Accordingly, altered RNA …

5-methylcytosine RNA methyltransferases and their potential roles in cancer

M Li, Z Tao, Y Zhao, L Li, J Zheng, Z Li… - Journal of translational …, 2022 - Springer
Abstract In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key
player in regulating RNA metabolism and function through coding as well as non-coding …

Deciphering epitranscriptome: modification of mRNA bases provides a new perspective for post-transcriptional regulation of gene expression

S Kumar, T Mohapatra - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Gene regulation depends on dynamic and reversibly modifiable biological and chemical
information in the epigenome/epitranscriptome. Accumulating evidence suggests that …

Dynamic transcriptomic m5C and its regulatory role in RNA processing

YS Chen, WL Yang, YL Zhao… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Abstract RNA 5‐methylcytosine (m5C) is a prevalent RNA modification in multiple RNA
species, including messenger RNAs (mRNAs), transfer RNAs (tRNAs), ribosomal RNAs …

The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark

L Trixl, A Lusser - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
It is a well‐known fact that RNA is the target of a plethora of modifications which currently
amount to over a hundred. The vast majority of these modifications was observed in the two …