Leptomeningeal carcinomatosis (MC) represents an uncommon, but devasting
manifestation of metastatic breast cancer. This is the first systematic review/pooled analysis …

Solid cancers develop in dynamically modified microenvironments in which they seem to
hijack resident and infiltrating nontumor cells, and exploit existing extracellular matrices and …

Purpose Leptomeningeal carcinomatosis (MC) is commonly associated with HER2-positive
breast cancer (HER2-BC), with a poor prognosis and no standardised treatment. We …

Central nervous system (CNS) metastasis from systemic cancers can involve the brain
parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura …

Drug delivery to the central nervous system (CNS) is complicated by the blood-brain barrier.
As a result, many agents that are found to be potentially effective at their site of action cannot …

Treatment of brain tumors with chemotherapy is limited mostly because of delivery
impediments related to the blood-brain barrier (BBB). For gliomas, the most common and …

Leptomeningeal Metastases (LM) is a turning point in terms of prognosis and quality of life of
patients with breast cancer (BC). Intrathecal therapy is largely used for the treatment of …

The meninges and choroid plexus perform many functions in the develo** and adult
human central nervous system (CNS) and are composed of a number of different cell types …

Background: Leptomeningeal disease (LMD) is a complication that results from solid tumor
metastasis. Prognosis is extremely poor. As therapeutic options for solid tumors improve, the …

OBJECTIVE Many pharmaceutical agents are highly potent but are unable to exert
therapeutic activity against disorders of the central nervous system (CNS), because the …