Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

Runx2 is an essential transcription factor for skeletal development. It is expressed in
multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a …

Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …

Runx2 (runt related transcription factor 2) and Sp7 (Sp7 transcription factor 7) are crucial
transcription factors for bone development. The cotranscription factor Cbfb (core binding …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

The Runt-related transcription factor (Runx) family plays various roles in the homeostasis of
cartilage. Here, we examined the role of Runx2 and Runx3 for osteoarthritis development in …

Osteoarthritis (OA) is the most common form of arthritis, is the leading cause of impaired
mobility in the elderly, and accounts for more than a third of chronic moderate to severe pain …

Background: S-adenosylhomocysteine (SAH) is a risk factor of cardiovascular disease;
inhibition of SAH hydrolase (SAHH) results in SAH accumulation and induces endothelial …

Background Osteoarthritis (OA) treatment aims to improve inflammation and delay cartilage
degeneration. However, there is no effective strategy presently available. Ononin, a …