Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Despite strong evidence supporting the heritability of major depressive disorder (MDD),
previous genome-wide studies were unable to identify risk loci among individuals of …

A major impediment to novel drug development has been the paucity of animal models that
accurately reflect symptoms of affective disorders. In animal models, prolonged social stress …

Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most
resisting the development of neuropsychiatric disorders. Over the past 5 years, there has …

For more than a century, clinical investigators have focused on early life as a source of adult
psychopathology. Early theories about psychic conflict and toxic parenting have been …

Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …