Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

I Akhlaghipour, AR Bina, MR Mogharrabi, A Fanoodi… - Human Genomics, 2022 - Springer
Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and
organs, including eyes, kidneys, and cardiovascular system. According to the World Health …

Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational Diabetes Mellitus Susceptibility: A Meta-analysis

W **e, L Zhang, J Wang, Y Wang - Biochemical Genetics, 2023 - Springer
Genetics plays a role in the development of gestational diabetes mellitus (GDM), which
poses serious risks to pregnant women and their children. Several studies have …

Association of an intronic SNP rs9939609 in FTO gene with type 2 diabetes mellitus among Bangladeshi population: A case–control study combined with updated …

K Kar, MA Munim, A Fariha, AS Roy, MI Rahman… - Human Gene, 2023 - Elsevier
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder, caused by both genetic
and environmental variables. The rs9939609 variant with a T> A mutation of the Fat mass …

Relationship between Functional miR-143/145 Cluster Variants and Susceptibility to Type 2 Diabetes Mellitus: A Preliminary Case-Control Study and Bioinformatics …

D Jahantigh, F Mirani Sargazi, S Sargazi… - Endocrine …, 2021 - Taylor & Francis
Purpose: To investigate the link between two variants (rs4705342 and rs4705343) in the
promoter of the miR-143/145 cluster with Type 2 diabetes mellitus (T2DM) risk. Methods: A …

SNPs in the 3′-untranslated region of SLC30A8 confer risk of type 2 diabetes mellitus in a south-east Iranian population: Evidences from case-control and …

S Sargazi, M Heidari Nia, FM Sargazi… - Journal of Diabetes & …, 2020 - Springer
Background Type 2 diabetes mellitus (T2DM) is a heterogenic disease with increasing
incidence. The SLC30A8 gene encodes an islet zinc transporter (ZnT8), and its variants …

SIRT1 functional polymorphisms (rs12778366, rs3758391) as genetic biomarkers of susceptibility to type 2 diabetes mellitus in Iranians: a case-control study and …

MB Sadeghi, A Nakhaee, R Saravani… - International Journal of …, 2021 - Springer
Introduction Genetic background is an important risk factor for type 2 diabetes mellitus
(T2DM). We designed this study to examine the role of rs12778366 and rs3758391, two …

Association of CYP7A1 and CYP2E1 Polymorphisms with Type 2 Diabetes in the Chinese Han Populations

L Zhang, J Tang, Y Wang, X Wang… - Pharmacogenomics and …, 2022 - Taylor & Francis
Background Type 2 diabetes mellitus (T2DM) is caused by diverse environmental and
genetic risk factors. Previous studies have reported that cytochrome P450 (CYP) is a …

Exploring histone deacetylases in type 2 diabetes mellitus: pathophysiological insights and therapeutic avenues

KK Kumar, EH Aburawi, M Ljubisavljevic, MKS Leow… - Clinical …, 2024 - Springer
Diabetes mellitus is a chronic disease that impairs metabolism, and its prevalence has
reached an epidemic proportion globally. Most people affected are with type 2 diabetes …

Association between genetic polymorphisms and gestational diabetes mellitus susceptibility in a Chinese population

Q Zeng, J Liu, X Liu, N Liu, W Wu, RG Watson… - Frontiers in …, 2024 - frontiersin.org
Background Although the association between HHEX, IGF2BP2, and FTO polymorphisms
and the risk of GDM has been investigated in several studies, the findings have been …

[HTML][HTML] Contribution of genetic variant identified in HHEX gene in the Overweight Saudi patients confirmed with Type 2 Diabetes Mellitus

M Alfaifi - Saudi Journal of Biological Sciences, 2022 - Elsevier
Background The rs7932837 polymorphism in the Hematopoietically expressed homeobox
(HHEX) gene was discovered through genome-wide association studies and is a promising …