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Isocyanide based [4+ 1] cycloaddition reactions: an indispensable tool in multi-component reactions (MCRs)
The advent of cycloaddition reactions in the synthesis of heterocycles and their ever
burgeoning applications in the fields of material chemistry, catalysis and drugs have been a …
burgeoning applications in the fields of material chemistry, catalysis and drugs have been a …
Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties
NA Liberto, JB Simões, S de Paiva Silva… - Bioorganic & medicinal …, 2017 - Elsevier
An efficient method for the synthesis of quinolines using microwave irradiation was
developed providing 28 quinolines with good yields. The reaction procedures are …
developed providing 28 quinolines with good yields. The reaction procedures are …
Tandem ring-opening and formal [3+ 2] cycloaddition of furo [2, 3-d] pyrimidine-2, 4-diones
L Huang, Y Han, J Sun, Q Sun, CG Yan - Organic & Biomolecular …, 2023 - pubs.rsc.org
The base promoted tandem annulation reaction of activated cyclic 1, 3-dipolarophiles such
as 2-arylidene-1, 3-indanediones, 2-(o-hydroxybenzylidene)-1, 3-indanediones and 3 …
as 2-arylidene-1, 3-indanediones, 2-(o-hydroxybenzylidene)-1, 3-indanediones and 3 …
A Four‐Component Domino Reaction: An Eco‐Compatible and Highly Efficient Construction of 1,8‐Naphthyridine Derivatives, Their In Silico Molecular Docking, Drug …
A multicomponent domino reaction of enaminone, malononitrile, and o‐phthalaldehyde has
been established, providing direct access to novel highly functionalized pentacyclic …
been established, providing direct access to novel highly functionalized pentacyclic …
PIDA-promoted metal-free [3+ 2] heteroannulation of β-ketothioamides with 4-hydroxy coumarins: chemo-/regioselective access to furo [3, 2-c] chromen-4-ones at …
Herein, we report a viable protocol to access furo [3, 2-c] chromen-4-ones by engaging
easily accessible 4-hydroxy coumarins as a three-atom CCO unit and thioamides as a C2 …
easily accessible 4-hydroxy coumarins as a three-atom CCO unit and thioamides as a C2 …
Synthesis of novel Furo [3, 2‐c] coumarin derivatives through multicomponent [4+ 1] cycloaddition reaction using ZnO/Fap as a sustainable catalyst
An efficient green protocol is developed for the synthesis of ten new furo [3, 2‐c] coumarin
derivatives employing zinc oxide loaded on fluorapatite (ZnO/FAp) as catalyst. The three …
derivatives employing zinc oxide loaded on fluorapatite (ZnO/FAp) as catalyst. The three …
Recent advances on sustainable synthesis of furocoumarins
Being an important constituent of naturally occurring heterocyclic compounds with a myriad
of interesting biological activities, the furocoumarin motif has claimed vast interest in …
of interesting biological activities, the furocoumarin motif has claimed vast interest in …
Highly efficient regioselective synthesis of pyrroles via a tandem enamine formation–Michael addition–cyclization sequence under catalyst-and solvent-free conditions
A convenient catalyst-free, three-component procedure was developed for the synthesis of
tetrasubstituted pyrroles under solvent-free conditions and in green solvents glycerol, PEG …
tetrasubstituted pyrroles under solvent-free conditions and in green solvents glycerol, PEG …
Two-Step Route to Diverse N-Functionalized Peptidomimetic-like Isatins through an Oxidation/Intramolecular Oxidative-Amidation Cascade of Ugi Azide and Ugi …
Two-step methodology described herein showcases the first example of an
oxidation/oxidative amidation cyclization cascade of MCR products toward diverse N …
oxidation/oxidative amidation cyclization cascade of MCR products toward diverse N …
Synthesis of fluorescent heterocycles via a Knoevenagel/[4+ 1]-cycloaddition cascade using acetyl cyanide
A concise one-pot three-component reaction that affords fluorescent indolizines, benzo [d]
pyrrolo [2, 1-b] thiazoles, and pyrrolo [1, 2-a] pyrazines is reported. The methodology …
pyrrolo [2, 1-b] thiazoles, and pyrrolo [1, 2-a] pyrazines is reported. The methodology …