Biosensor technology: recent advances in threat agent detection and medicine

J Kirsch, C Siltanen, Q Zhou, A Revzin… - Chemical Society …, 2013 - pubs.rsc.org
Biosensors are of great significance because of their capability to resolve a potentially large
number of analytical problems and challenges in very diverse areas such as defense …

Sensing the deadliest toxin: technologies for botulinum neurotoxin detection

P Čapek, TJ Dickerson - Toxins, 2010 - mdpi.com
Sensitive and rapid detection of botulinum neurotoxins (BoNTs), the most poisonous
substances known to date, is essential for studies of medical applications of BoNTs and …

Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid

MB Nowakowska, K Selby, A Przykopanski… - Scientific Reports, 2022 - nature.com
Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium
botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite …

Immuno-PCR: achievements and perspectives

DY Ryazantsev, DV Voronina, SK Zavriev - Biochemistry (Moscow), 2016 - Springer
The immuno-PCR (iPCR) method combines advantages of enzyme-linked immunosorbent
assay and polymerase chain reaction, which is used in iPCR as a method of “visualization” …

Quantum dot immunoassays in renewable surface column and 96-well plate formats for the fluorescence detection of botulinum neurotoxin using high-affinity …

MG Warner, JW Grate, A Tyler, RM Ozanich… - Biosensors and …, 2009 - Elsevier
A fluorescence sandwich immunoassay using high-affinity antibodies and quantum dot (QD)
reporters has been developed for detection of botulinum neurotoxin serotype A (BoNT/A) …

Effects of purification on the bioavailability of botulinum neurotoxin type A

LW Cheng, B Onisko, EA Johnson, JR Reader… - Toxicology, 2008 - Elsevier
Botulinum neurotoxins (BoNTs) are among the most potent biological toxins for humans.
They are primarily produced by the gram-positive, anaerobic spore-forming bacterium …

Self-assembled peptide monolayers as a toxin sensing mechanism within arrayed microchannels

ML Frisk, WH Tepp, EA Johnson, DJ Beebe - Analytical chemistry, 2009 - ACS Publications
A sensor for the lethal bacterial enzyme, botulinum neurotoxin type A (BoNT/A), was
developed using self-assembled monolayers (SAMs). SAMs consisting of an immobilized …

Evaluation of false positive responses by mass spectrometry and ion mobility spectrometry for the detection of trace explosives in complex samples

CL Crawford, HH Hill Jr - Analytica chimica acta, 2013 - Elsevier
Secondary electrospray ionization-ion mobility-time of flight mass spectrometry (SESI-IM-
TOFMS) was used to evaluate common household products and food ingredients for any …

Mass spectrometric detection of protein-based toxins

A Tevell Åberg, K Björnstad… - … strategy, practice, and …, 2013 - liebertpub.com
This review focuses on mass spectrometric detection of protein-based toxins, which are
among the most toxic substances known. Special emphasis is given to the bacterial toxins …

Advances in assays and analytical approaches for botulinum-toxin detection

JW Grate, RM Ozanich Jr, MG Warner… - TrAC Trends in …, 2010 - Elsevier
We review methods to detect botulinum toxin, the most poisonous substance known. Current
assays are being developed with two main objectives in mind: We emphasize the diverse …