The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer a promising cell-
based therapy for myocardial infarction. However, the presence of transitory ventricular …

Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …

The immature phenotype of human pluripotent stem cell derived cardiomyocytes (hPSC-
CMs) constrains their potential in cell therapy and drug testing. In this study, we report that …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a
powerful tool for human disease modeling and therapeutic testing. However, their use …

Cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are increasingly used to
model cardiac disease, test drug efficacy and for safety pharmacology. Nevertheless, a …

Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

The therapeutic success of human stem cell-derived cardiomyocytes critically depends on
their ability to respond to and integrate with the surrounding electromechanical environment …