Trends in antidiabetic drug discovery: FDA approved drugs, new drugs in clinical trials and global sales

AD Dahlén, G Dashi, I Maslov, MM Attwood… - Frontiers in …, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM) continues to be a substantial medical problem due to its
increasing global prevalence and because chronic hyperglycemic states are closely linked …

Pharmacotherapy of type 2 diabetes: An update and future directions

A DeMarsilis, N Reddy, C Boutari, A Filippaios… - Metabolism, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

[HTML][HTML] Advances in research on type 2 diabetes mellitus targets and therapeutic agents

J Su, Y Luo, S Hu, L Tang, S Ouyang - International Journal of Molecular …, 2023 - mdpi.com
Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the
treatment of which can only delay and prolong the terminal stage of the disease, ie, type 2 …

Oat phenolic compounds regulate metabolic syndrome in high fat diet-fed mice via gut microbiota

L Dong, C Qin, Y Li, Z Wu, L Liu - Food Bioscience, 2022 - Elsevier
This study aimed to better understand the beneficial effect of oat phenolic compounds (OPC)
in improving metabolic syndrome via regulating metabolites and gut microbiota composition …

A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant

I Purwaningsih, IP Maksum, D Sumiarsa, S Sriwidodo - Molecules, 2023 - mdpi.com
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia caused
by resistance to insulin action, inadequate insulin secretion, or excessive glucagon …

Multi-target approaches in metabolic syndrome

FF Lillich, JD Imig, E Proschak - Frontiers in pharmacology, 2021 - frontiersin.org
Metabolic syndrome (MetS) is a highly prevalent disease cluster worldwide. It requires
polypharmacological treatment of the single conditions including type II diabetes …

Synthetic approaches to the new drugs approved during 2022

SP France, EA Lindsey, EL McInturff… - Journal of medicinal …, 2024 - ACS Publications
In 2022, 23 new small molecule chemical entities were approved as drugs by the United
States FDA, European Union EMA, Japan PMDA, and China NMPA. This review describes …

[HTML][HTML] Associations between both legacy and alternative per-and polyfluoroalkyl substances and glucose-homeostasis: The Isomers of C8 health project in China

YT Zhang, M Zeeshan, F Su, ZM Qian, SD Geiger… - Environment …, 2022 - Elsevier
Background Epidemiological studies on the associations of legacy per-and polyfluoroalkyl
substances (PFASs) and glucose homeostasis remain discordant. Understanding of PFAS …

Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD

Z Zhang, G Ji, M Li - Frontiers in endocrinology, 2023 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide, affected by
both genetics and environment. Type 2 diabetes (T2D) stands as an independent …

Effects of oral glucose-lowering agents on gut microbiota and microbial metabolites

D Wang, J Liu, L Zhou, Q Zhang, M Li… - Frontiers in …, 2022 - frontiersin.org
The current research and existing facts indicate that type 2 diabetes mellitus (T2DM) is
characterized by gut microbiota dysbiosis and disturbed microbial metabolites. Oral glucose …