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Natural product synthesis in the age of scalability
CA Kuttruff, MD Eastgate, PS Baran - Natural product reports, 2014 - pubs.rsc.org
The ability to procure useful quantities of a molecule by simple, scalable routes is emerging
as an important goal in natural product synthesis. Approaches to molecules that yield …
as an important goal in natural product synthesis. Approaches to molecules that yield …
Probing the biology of natural products: molecular editing by diverted total synthesis
AM Szpilman, EM Carreira - Angewandte Chemie International …, 2010 - Wiley Online Library
The systematic modification of natural products through diverted total synthesis is a powerful
concept for the systematic modification of natural products with the aim of studying …
concept for the systematic modification of natural products with the aim of studying …
[PDF][PDF] Continuous‐flow synthesis of the anti‐malaria drug artemisinin
F Lévesque, PH Seeberger - Angewandte Chemie International …, 2012 - academia.edu
Malaria remains a major global health problem, killing about one million people each year,
with the protozoan parasite Plasmodium falciparum responsible for this most deadly illness …
with the protozoan parasite Plasmodium falciparum responsible for this most deadly illness …
Semisynthetic artemisinin, the chemical path to industrial production
J Turconi, F Griolet, R Guevel, G Oddon… - … Process Research & …, 2014 - ACS Publications
A new commercial-scale alternative manufacturing process to produce a complementary
source of artemisinin to supplement the plant-derived supply is described by conversion of …
source of artemisinin to supplement the plant-derived supply is described by conversion of …
From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements
RK Haynes - Current topics in medicinal chemistry, 2006 - ingentaconnect.com
The artemisinin derivatives, dihydroartemisinin (DHA), artesunate, atemether and arteether,
are currently used for treatment of malaria in artemisinin combination therapies (ACT) with …
are currently used for treatment of malaria in artemisinin combination therapies (ACT) with …
A concise synthesis of (+)-artemisinin
C Zhu, SP Cook - Journal of the American Chemical Society, 2012 - ACS Publications
Malaria represents one of the most medically and economically debilitating diseases
present in the world today. Fortunately, there exists a highly effective treatment based on the …
present in the world today. Fortunately, there exists a highly effective treatment based on the …
The mechanism of the spontaneous autoxidation of dihydroartemisinic acid
LK Sy, GD Brown - Tetrahedron, 2002 - Elsevier
Dihydroartemisinic acid undergoes slow spontaneous autoxidation to artemisinin and other
natural products, which have been reported from the medicinal plant Artemisia annua. The …
natural products, which have been reported from the medicinal plant Artemisia annua. The …
Transgenic approach to increase artemisinin content in Artemisia annua L.
Artemisinin, the endoperoxide sesquiterpene lactone, is an effective antimalarial drug
isolated from the Chinese medicinal plant Artemisia annua L. Due to its effectiveness …
isolated from the Chinese medicinal plant Artemisia annua L. Due to its effectiveness …
Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research
Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …
A brief overview of classical natural product drug synthesis and bioactivity
G Li, M Lou, X Qi - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Traditional medicines consisting of compounds derived from natural organisms have been
used for human health care worldwide since ancient times. Since the last century, huge …
used for human health care worldwide since ancient times. Since the last century, huge …