Natural product synthesis in the age of scalability

CA Kuttruff, MD Eastgate, PS Baran - Natural product reports, 2014 - pubs.rsc.org
The ability to procure useful quantities of a molecule by simple, scalable routes is emerging
as an important goal in natural product synthesis. Approaches to molecules that yield …

Probing the biology of natural products: molecular editing by diverted total synthesis

AM Szpilman, EM Carreira - Angewandte Chemie International …, 2010 - Wiley Online Library
The systematic modification of natural products through diverted total synthesis is a powerful
concept for the systematic modification of natural products with the aim of studying …

[PDF][PDF] Continuous‐flow synthesis of the anti‐malaria drug artemisinin

F Lévesque, PH Seeberger - Angewandte Chemie International …, 2012 - academia.edu
Malaria remains a major global health problem, killing about one million people each year,
with the protozoan parasite Plasmodium falciparum responsible for this most deadly illness …

Semisynthetic artemisinin, the chemical path to industrial production

J Turconi, F Griolet, R Guevel, G Oddon… - … Process Research & …, 2014 - ACS Publications
A new commercial-scale alternative manufacturing process to produce a complementary
source of artemisinin to supplement the plant-derived supply is described by conversion of …

From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements

RK Haynes - Current topics in medicinal chemistry, 2006 - ingentaconnect.com
The artemisinin derivatives, dihydroartemisinin (DHA), artesunate, atemether and arteether,
are currently used for treatment of malaria in artemisinin combination therapies (ACT) with …

A concise synthesis of (+)-artemisinin

C Zhu, SP Cook - Journal of the American Chemical Society, 2012 - ACS Publications
Malaria represents one of the most medically and economically debilitating diseases
present in the world today. Fortunately, there exists a highly effective treatment based on the …

The mechanism of the spontaneous autoxidation of dihydroartemisinic acid

LK Sy, GD Brown - Tetrahedron, 2002 - Elsevier
Dihydroartemisinic acid undergoes slow spontaneous autoxidation to artemisinin and other
natural products, which have been reported from the medicinal plant Artemisia annua. The …

Transgenic approach to increase artemisinin content in Artemisia annua L.

K Tang, Q Shen, T Yan, X Fu - Plant cell reports, 2014 - Springer
Artemisinin, the endoperoxide sesquiterpene lactone, is an effective antimalarial drug
isolated from the Chinese medicinal plant Artemisia annua L. Due to its effectiveness …

Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research

OPS Patel, RM Beteck, LJ Legoabe - European journal of medicinal …, 2021 - Elsevier
Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …

A brief overview of classical natural product drug synthesis and bioactivity

G Li, M Lou, X Qi - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Traditional medicines consisting of compounds derived from natural organisms have been
used for human health care worldwide since ancient times. Since the last century, huge …