Based on their pharmacological properties, psychoactive drugs are supposed to take control
of the natural reward system to finally drive compulsory drug seeking and consumption …

An increasing emphasis has been placed on the development and use of animal models of
addiction that capture defining features of human drug addiction, including escalation/binge …

Drugs of abuse are thought to promote addiction in part by “hijacking” brain reward systems,
but the underlying mechanisms remain undefined. Using whole-brain FOS map** and in …

We recently introduced an animal model of incubation of methamphetamine craving after
choice-based voluntary abstinence in male rats. Here we studied the generality of this …

We recently developed a rat model of incubation of methamphetamine craving after choice-
based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and …

Clinical evidence suggest that men are more sensitive than women to the abuse-related
effects of mu-opioid agonists. In contrast, preclinical studies suggest the opposite sex …

The interaction between social factors and alcohol addiction is complex, with potential for
both positive and negative contributions to drug use and abstinence. Positive social …

Background and Purpose Studies using intermittent‐access drug self‐administration show
increased motivation to take and seek cocaine and fentanyl, relative to continuous access. In …

Alcohol and drug use can dysregulate neural circuit function to produce a wide range of
neuropsychiatric disorders, including addiction. To understand the neural circuit …

Since the first experimental hint for the existence of “an actual desire or striving for the drug”
in nonhuman animals by Sidney Spragg in the late 1930s, much effort has been expended …