Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …

The brain is composed of many lipids with varied forms that serve not only as structural
components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an …

Background In the extracellular environment, lysophosphatidic acid (LPA) species are
generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors …

Stroke penumbra injury caused by excess glutamate is an important factor in determining
stroke outcome; however, several therapeutic approaches aiming to rescue the penumbra …

Background A range of neurological pathologies may lead to secondary hydrocephalus.
Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as …

A major consequence of traumatic brain and spinal cord injury is the loss of the myelin
sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system …

Both astrocytic and microglial functions have been extensively investigated in healthy
subjects and neurodegenerative diseases. For astrocytes, not only various sub-types were …

Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic
acid receptors (LPARs), named LPA 1-LPA 6. These receptors initiate signaling cascades …

Background Microglia, the immunocompetent cells of the CNS, rapidly respond to brain
injury and disease by altering their morphology and phenotype to adopt an activated state …

Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many
physiological functions that signals through six known G-protein-coupled receptors (LPA1 …