The ICH quality vision introduced the concept of quality by design (QbD), which requires a
greater understanding of the raw material attributes, of process parameters, of their …

Bionanotechnology investigates the interactions between nanoscale materials and
biological systems and creates the technologies for interfacing the two [1–4]. Potential …

" Polymorphism in the Pharmaceutical Industry-Solid Form and Drug Development"
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …

Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized
from a-cellulose precursor (type Iẞ), obtained as a pulp from fibrous plant material, with …

This study presents a framework for process and product development on a continuous
direct compression manufacturing platform. A challenging sustained release formulation …

Highlights•Cyclodextrins are complexing excipients in tablets mainly for potent
drugs.•Methods to enhance the complexation efficiency decrease the cyclodextrin …

Disintegration performance was measured by analysing both water ingress and tablet
swelling of pure microcrystalline cellulose (MCC) and in mixture with croscarmellose sodium …

In this work a continuous direct compression process was developed for a low-dosed drug
product. Each unit operation of the GEA CDC-50 system was thoroughly investigated. This …

The use of chitosan as a potential excipient in pharmaceutical formulations for the delivery of
drugs produced via direct compression tableting has been investigated. Chitosan, N …

A theophylline monohydrate (THm) powder, with particle size and shape substantially
similar to a theophylline anhydrate powder, was prepared by vapor-mediated phase …