Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

Pleiotropy refers to the phenomenon of one gene or one mutation affecting multiple
phenotypic traits. While the concept of pleiotropy is as old as Mendelian genetics, functional …

In the post-genomic era, the elucidation of the relationship between the molecular origins of
diseases and their resulting phenotypes is a crucial task for medical research. Here, we use …

We present a systematic review of pleiotropy among SNPs and genes reported to show
genome-wide association with common complex diseases and traits. We find abundant …

Pleiotropy is the well-established phenomenon of a single gene affecting multiple traits. It
has long played a central role in theoretical, experimental, and clinical research in genetics …

It was first noticed 100 years ago that mutations tend to affect more than one phenotypic
characteristic, a phenomenon that was called'pleiotropy'. Because pleiotropy was found so …

Protein complexes are key molecular entities that integrate multiple gene products to
perform cellular functions. Here we report the first genome-wide screen for complexes in an …

Current yeast interactome network maps contain several hundred molecular complexes with
limited and somewhat controversial representation of direct binary interactions. We carried …

Genetics aims to understand the relation between genotype and phenotype. However,
because complete deletion of most yeast genes (∼ 80%) has no obvious phenotypic …

Is genetic evolution predictable? Evolutionary developmental biologists have argued that, at
least for morphological traits, the answer is a resounding yes. Most mutations causing …