Advances in drug delivery systems, challenges and future directions

TC Ezike, US Okpala, UL Onoja, CP Nwike, EC Ezeako… - Heliyon, 2023 - cell.com
Advances in molecular pharmacology and an improved understanding of the mechanism of
most diseases have created the need to specifically target the cells involved in the initiation …

Mesoporous silica materials: From physico-chemical properties to enhanced dissolution of poorly water-soluble drugs

A Maleki, H Kettiger, A Schoubben… - Journal of Controlled …, 2017 - Elsevier
New approaches in pharmaceutical chemistry have resulted in more complex drug
molecules in the quest to achieve higher affinity to their targets. However, these 'highly …

Self-microemulsifying drug delivery system (SMEDDS)–challenges and road ahead

S Dokania, AK Joshi - Drug delivery, 2015 - Taylor & Francis
Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to
formulate poor water soluble compounds for bioavailability enhancement. However, certain …

Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and …

C Rathore, C Hemrajani, AK Sharma, PK Gupta… - Drug Delivery and …, 2023 - Springer
Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound
obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability …

Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability

TH Tran, Y Guo, D Song, RS Bruno, X Lu - Journal of pharmaceutical …, 2014 - Elsevier
Quercetin is a dietary flavonoid with potential chemoprotective effects, but has low
bioavailability because of poor aqueous solubility and low intestinal absorption. A quercetin …

Self-nanoemulsifying drug delivery system (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: Design, optimization, in vitro and in …

AA Kassem, AM Mohsen, RS Ahmed… - Journal of molecular …, 2016 - Elsevier
The aim of the present study is to develop and optimize self-nanoemulsifying drug delivery
systems (SNEDDSs) to improve the per-oral bioavailability of poorly soluble polyene …

Optimized self nano-emulsifying systems of ezetimibe with enhanced bioavailability potential using long chain and medium chain triglycerides

S Bandyopadhyay, OP Katare, B Singh - Colloids and Surfaces B …, 2012 - Elsevier
The objective of the current work is to develop systematically optimized self-nanoemulsifying
drug delivery systems (SNEDDS) using long chain triglycerides (LCT's) and medium chain …

Improved pharmacodynamic potential of rosuvastatin by self-nanoemulsifying drug delivery system: An in vitro and in vivo evaluation

R Verma, A Kaushik, R Almeer… - International journal …, 2021 - Taylor & Francis
Purpose The purpose of this proposed research was to investigate a nano-formulation
developed using self-nanoemulsifying drug delivery system (SNEDDS) to improve the …

Nanoemulsion liquid preconcentrates for raloxifene hydrochloride: optimization and in vivo appraisal

MA Elsheikh, YSR Elnaggar, EY Gohar… - International Journal of …, 2012 - Taylor & Francis
Raloxifene hydrochloride (RLX) is a selective estrogen-receptor modulator for treatment of
osteoporosis and prevention of breast and endometrial cancer. By virtue of extensive …

Novel Self-Nano Emulsifying Drug Delivery System (SNEDDS) of andrographolide isolated from Andrographis paniculata Nees: Characterization, in-vitro and in-vivo …

Y Syukri, R Martien, E Lukitaningsih… - Journal of Drug Delivery …, 2018 - Elsevier
This study aimed to conduct a preparation and characterization of andrographolide isolated
from Andrographis paniculata Nees (AND)-loaded Self-Nano Emulsifying Drug Delivery …