Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways
The discovery and clinical implementation of immune-checkpoint inhibitors (ICIs) targeting
CTLA4, PD-1 and PD-L1 has revolutionized the treatment of cancer, as recognized by the …
CTLA4, PD-1 and PD-L1 has revolutionized the treatment of cancer, as recognized by the …
The evasion mechanisms of cancer immunity and drug intervention in the tumor microenvironment
SK Kim, SW Cho - Frontiers in pharmacology, 2022 - frontiersin.org
Recently, in the field of cancer treatment, the paradigm has changed to immunotherapy that
activates the immune system to induce cancer attacks. Among them, immune checkpoint …
activates the immune system to induce cancer attacks. Among them, immune checkpoint …
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
MLJ Watson, PDA Vignali, SJ Mullett… - Nature, 2021 - nature.com
Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …
CD8+ T cell metabolism in infection and cancer
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …
malignant cells and can provide long-term protective immunity. In the response to infection …
Comprehensive metabolomics expands precision medicine for triple-negative breast cancer
Y ** of triple-negative breast cancer reveals potential therapeutic targets
Y Gong, P Ji, YS Yang, S ** dietary interventions as therapy for cancer
Cancer cells acquire distinct metabolic preferences based on their tissue of origin, genetic
alterations and degree of interaction with systemic hormones and metabolites. These …
alterations and degree of interaction with systemic hormones and metabolites. These …
Metabolic landscape of the tumor microenvironment at single cell resolution
The tumor milieu consists of numerous cell types each existing in a different environment.
However, a characterization of metabolic heterogeneity at single-cell resolution is not …
However, a characterization of metabolic heterogeneity at single-cell resolution is not …
Reimagining IDO pathway inhibition in cancer immunotherapy via downstream focus on the tryptophan–kynurenine–aryl hydrocarbon axis
Significant progress has been made in cancer immunotherapy with checkpoint inhibitors
targeting programmed cell death protein 1 (PD-1)–programmed death-ligand 1 signaling …
targeting programmed cell death protein 1 (PD-1)–programmed death-ligand 1 signaling …
Serine, glycine and one-carbon metabolism in cancer
S Pan, M Fan, Z Liu, X Li… - … Journal of Oncology, 2020 - spandidos-publications.com
Serine/glycine biosynthesis and one-carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …