The pyrazole-4-carboxamide scaffold containing a flexible amide chain has emerged as the
molecular skeleton of highly efficient agricultural fungicides targeting succinate …

A novel series of 19 quinoline/1, 2, 4-triazole hybrid 6a-i and 7a-j was synthesized and
evaluated in vitro as dual COX-2/5-LOX inhibitors. Compounds 6e, 6i, and 7e displayed the …

Triazole is an imperative heterocycle renowned for its broad-spectrum biological
significance. In this manuscript, facile microwave-assisted synthesis of a series of 4 …

Abstract A reaction of 2-(4, 4, 6-trimethyl-2-oxo-4 H-pyrrolo [3, 2, 1-ij] quinoline-1-ylidene)-
hydrazinocarbothioamides with α-halocarbonyl compounds, such as ethyl bromocetate and …

Abstract The inhibition of phosphatidylinositol‐4, 5‐bisphosphate 3‐kinase catalytic subunit
alpha (PIK3CA) protein could be a promising treatment for breast cancer. In this regard …

A family of novel thiazole-based hydrazide derivatives bearing the 4-aminoquinazoline
moiety were designed and synthesized by the molecular hybridization strategy, and …

A series of novel 8‐bromo‐1H‐1, 2, 3‐triazol‐4‐yl‐2‐methylquinoline derivatives and their
Suzuki coupling products were synthesized via Copper catalyzed azide‐alkyne …

A coupled reaction between 1H-1, 2, 4-triazole-3, 5-diamine and carboxylic acids was
studied to synthesize new amido-1H-1, 2, 4-triazoles derivatives (1–5), under various …

The clinical success of phyto-chemicals and computationally assisted drug discovery-
derived agents has stimulated the development of novel compounds for human illnesses. In …

In this work, hydrazone, thiosemicarbazide, diamide, and dipeptide derivatives were
prepared from the glycine and β-alanine hydrazide of 4-hydroxy-2-oxoquinoline. The …