The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

Abstract Changes in the composition of gut-associated microbial communities may underlie
many inflammatory and allergic diseases. However, the processes that help maintain a …

Citrobacter rodentium is an extracellular enteric mouse-specific pathogen used to model
infections with human pathogenic Escherichia coli and inflammatory bowel disease. C …

Abstract Cytokines IL-17 and IL-22 play pivotal roles in host defense against microbes and
in the development of chronic inflammatory diseases. These cytokines are produced by cells …

Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively
studied since its discovery in 2000. This review article aims to describe the cellular sources …

Interleukin 22 (IL-22), a member of the IL-10 cytokine family and is an emerging CD4+ Th
cytokine that plays an important role in anti-microbial defense, homeostasis and tissue …

Repair of the intestinal epithelium is tightly regulated to maintain homeostasis. The response
after epithelial damage needs to be local and proportional to the insult. How different types …

Tumor necrosis factor (TNF) is a pleiotropic inflammatory cytokine that mediates
antimicrobial defense and granuloma formation in response to infection by numerous …

Buisine MP, Desreumaux P, Leteurtre E, Copin MC, Colombel JF, Porchet N, Aubert JP.
Mucin gene expression in intestinal epithelial cells in Crohn's disease. Gut (2001) doi …

Clostridium difficile infection (CDI) is a major public health threat worldwide. The use of
nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with enhanced susceptibility to …