Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which is
characterized by the primary risk factor, age. Several attempts have been made to treat AD …

Alzheimer's disease (AD) is the most common form of dementia among the elderly,
accounting for 60% to 70% of cases. At present, the pathogenesis of this condition remains …

Gastrodin, which is extracted from the Chinese herbal medicine Gastrodia elata Blume, can
ameliorate neurogenesis after cerebral ischemia. However, it's possible underlying …

Increasing human life expectancy prompts the development of novel remedies for cognitive
decline: 44 million people worldwide are affected by dementia, and this number is predicted …

Abstract Alzheimer's disease (AD), one of the greatest threats to human health, is
characterized by declined cognition and changed behavior. Cyclic adenosine …

Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …

Phosphodiesterase 4 (PDE4), mainly present in immune, epithelial, and brain cells,
represents a family of key enzymes for the degradation of cyclic adenosine monophosphate …

Meta-analysis of genome-wide association study data has implicated PDE4B in the
pathogenesis of Alzheimer's disease (AD), the leading cause of senile dementia. PDE4B …

Inhibition of phosphodiesterase 2 and 4 (PDE2A and PDE4) increases the intracellular
cAMP and/or cGMP levels, which may prevent Amyloid β 42 oligomers (Aβ) related cognitive …

Background Phosphodiesterase-5 inhibitors (PDE5i) have been evaluated as a novel
treatment for Alzheimer's disease and related dementias (ADRD), but two recent cohort …