It has been amply constated that sugar ligand multivalency increases lectin-binding avidities
dramatically, thereby modulating the capacity of carbohydrates to participate in …

Carbohydrates are of great importance in a variety of biological processes, including but not
limited to, energy production, energy storage, protein recognition, immune response, and …

Click chemistry was extensively used to decorate synthetic multivalent scaffolds with glycans
to mimic the cell surface glycocalyx and to develop applications in glycosciences …

Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical
laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of …

Selective DC-SIGN targeting vs. langerin might lead to anti-infective agents, given their
counteracting effects upon infection by some pathogens. Here we show that multivalent sp2 …

Carbonic anhydrases (CAs) continue to represent a relevant pharmaceutical target. The
need of selective inhibitors and the involvement of these metalloenzymes in many …

Type 2 diabetes mellitus is a metabolic dreadful disease caused by an uncontrolled glucose
level in the bloodstream, particularly high after a meal. Inhibitors of glucosidases, involved in …

In this study, a synthetic approach is reported for generating hepta-branched β-cyclodextrins
(CDs) bearing heterogeneous carbohydrate residues at their primary side via a one-pot …