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Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …
among the most frequent causes of disability and death worldwide. Current treatment …
Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke
X Li, Z Han, T Wang, C Ma, H Li, H Lei, Y Yang… - Biomaterials, 2022 - Elsevier
Oxidative stress and mitochondrial damage are the main mechanisms of ischemia-
reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free …
reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free …
Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?
Y Qiu, C Zhang, A Chen, H Wang, Y Zhou… - Frontiers in …, 2021 - frontiersin.org
Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …
[HTML][HTML] Factors influencing the blood-brain barrier permeability
Y Zhao, L Gan, L Ren, Y Lin, C Ma, X Lin - Brain research, 2022 - Elsevier
The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …
blood-borne, endogenous and exogenous substances and maintains the homeostatic …
Neuroinflammation: friend and foe for ischemic stroke
Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …
perspective with the emergence of new ideas on neurodegeneration. The concept that …
[HTML][HTML] Blood–brain barrier breakdown in Alzheimer's disease: Mechanisms and targeted strategies
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …
Pathophysiology of blood–brain barrier permeability throughout the different stages of ischemic stroke and its implication on hemorrhagic transformation and recovery
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …
nervous system homeostasis. Its unique characteristics allow protecting the brain from …
Glial cells: role of the immune response in ischemic stroke
S Xu, J Lu, A Shao, JH Zhang, J Zhang - Frontiers in immunology, 2020 - frontiersin.org
Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …
Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …
critical to neuronal function while simultaneously excluding neurotoxic substances from the …