Oxygen is critical to the survival, function and fate of mammalian cells. Oxygen tension
controls cellular behavior through metabolic programming, which in turn controls tissue …

The tumor microenvironment (TME) demonstrates distinct hallmarks, including acidosis,
hypoxia, reactive oxygen species (ROS) generation, and altered ion fluxes, which are crucial …

Hepatic in vitro models that accurately replicate phenotypes and functionality of the human
liver are needed for applications in toxicology, pharmacology and biomedicine. Notably, it …

Human pluripotent stem cells (hPSCs) are intrinsically able to self-organize into cerebral
organoids that mimic features of develo** human brain tissue. These three-dimensional …

Cell cultures, organs-on-chip and microphysiological systems become increasingly relevant
as in vitro models, eg, in drug development, disease modelling, toxicology or cancer …

After the development of 3D cell culture methods in the middle of the last century and the
plethora of data generated with this culture configuration up to date, it could be shown that a …

Polymer-encapsulated dye nanoparticle sensors are a valuable approach to achieving in
situ analyte measurements with luminescence; however, typical emulsion-based …

Oxygen concentration measurement in 3D hydrogels is vital in 3D cell culture and tissue
engineering. However, standard 3D imaging systems capable of measuring oxygen …

Understanding the influence of oxygen tension on cellular functions and behaviors is crucial
for investigating various physiological and pathological conditions. In vitro cell culture …

In this work, we combine astigmatic particle tracking with phosphorescence decay
measurements to determine 3D oxygen concentration distributions in microfluidic systems …