Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …

Both cardio-and microvascular complications adversely affect the life quality of patients with
diabetes and have been the leading cause of mortality and morbidity in this population …

Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are
poised to transduce signals emanating from the cell surface. Cell membranes provide the …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

As biologics used in the clinic outpace the number of new small molecule drugs, an
important challenge for their efficacy and widespread use has emerged, namely tissue …

Highlights•Protein–protein interactions are essential for almost all cell processes.•Peptides
are ideal candidates for targeting protein–protein interactions (PPIs).•We survey screening …

PKC (protein kinase C) has been in the limelight since the discovery three decades ago that
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …

Protein kinases are one of the most significant drug targets in the human proteome,
historically harnessed for the treatment of cancer, cardiovascular disease, and a growing …