The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

The retinoblastoma protein RB and the transcription factor p53 are central tumor
suppressors. They are often found inactivated in various tumor types. Both proteins play …

Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …

The TP53 tumor suppressor gene is frequently mutated in human cancers. An analysis of
five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53
suppresses tumorigenesis by transcriptionally regulating a network of target genes that play …

CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-
wide screens in human cells,–. Whereas some cell types are amenable to genome …