Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

Nanodelivery of nucleic acids

BB Mendes, J Conniot, A Avital, D Yao… - Nature reviews …, 2022 - nature.com
There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of
gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented …

The effects of protein corona on in vivo fate of nanocarriers

Q **ao, M Zoulikha, M Qiu, C Teng, C Lin, X Li… - Advanced Drug Delivery …, 2022 - Elsevier
With the emerging advances in utilizing nanocarriers for biomedical applications, a
molecular-level understanding of the in vivo fate of nanocarriers is necessary. After …

'Passive'nanoparticles for organ-selective systemic delivery: design, mechanism and perspective

L Fu, Y Zhang, RA Farokhzad, BB Mendes… - Chemical Society …, 2023 - pubs.rsc.org
Nanotechnology has shown tremendous success in the drug delivery field for more effective
and safer therapy, and has recently enabled the clinical approval of RNA medicine, a new …

The protein corona and its effects on nanoparticle-based drug delivery systems

H Li, Y Wang, Q Tang, D Yin, C Tang, E He, L Zou… - Acta biomaterialia, 2021 - Elsevier
In most cases, once nanoparticles (NPs) enter the blood, their surface is covered by
biological molecules, especially proteins, forming a so-called protein corona (PC). As a …

Interplay between extracellular polymeric substances (EPS) from a marine diatom and model nanoplastic through eco-corona formation

G Grassi, E Gabellieri, P Cioni, E Paccagnini… - Science of The Total …, 2020 - Elsevier
The occurrence of nanoplastics in oceans' surface waters is no more a hypothesis and it
could severely affect marine organisms from different trophic levels. Nanoscale particles …

The Janus of Protein Corona on nanoparticles for tumor targeting, immunotherapy and diagnosis

X Wang, W Zhang - Journal of Controlled Release, 2022 - Elsevier
The therapeutics based on nanoparticles (NPs) are considered as the promising strategy for
tumor detection and treatment. However, one of the most challenges is the adsorption of …

Progress and prospects of magnetic iron oxide nanoparticles in biomedical applications: A review

N Elahi, M Rizwan - Artificial Organs, 2021 - Wiley Online Library
Nanoscience has been considered as one of the most substantial research in modern
science. The utilization of nanoparticle (NP) materials provides numerous advantages in …

Regulating protein corona formation and dynamic protein exchange by controlling nanoparticle hydrophobicity

Q Yu, L Zhao, C Guo, B Yan, G Su - Frontiers in bioengineering and …, 2020 - frontiersin.org
Physiochemical properties of engineered nanoparticles (NPs) play a vital role in nano-bio
interactions, which are critical for nanotoxicity and nanomedicine research. To understand …

Unveiling the pitfalls of the protein corona of polymeric drug nanocarriers

G Berrecoso, J Crecente-Campo, MJ Alonso - Drug delivery and …, 2020 - Springer
The protein corona is a natural protein layer spontaneously formed around nanomaterials
when exposed to biological media. This layer can alter the nanosystems' biological …