Towards a genomics-informed, real-time, global pathogen surveillance system

JL Gardy, NJ Loman - Nature Reviews Genetics, 2018 - nature.com
Abstract The recent Ebola and Zika epidemics demonstrate the need for the continuous
surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast …

[HTML][HTML] Next-generation sequencing technologies and their application to the study and control of bacterial infections

J Besser, HA Carleton, P Gerner-Smidt… - Clinical microbiology …, 2018 - Elsevier
Background With the efficiency and the decreasing cost of next-generation sequencing, the
technology is being rapidly introduced into clinical and public health laboratory practice …

VFDB 2019: a comparative pathogenomic platform with an interactive web interface

B Liu, D Zheng, Q **, L Chen, J Yang - Nucleic acids research, 2019 - academic.oup.com
The virulence factor database (VFDB, http://www. mgc. ac. cn/VFs/) is devoted to providing
the scientific community with a comprehensive warehouse and online platform for …

In Silico Genoty** of Escherichia coli Isolates for Extraintestinal Virulence Genes by Use of Whole-Genome Sequencing Data

AM Malberg Tetzschner, JR Johnson… - Journal of clinical …, 2020 - journals.asm.org
ABSTRACT Extraintestinal pathogenic Escherichia coli (ExPEC) is the leading cause in
humans of urinary tract infection and bacteremia. The previously published web tool …

PointFinder: a novel web tool for WGS-based detection of antimicrobial resistance associated with chromosomal point mutations in bacterial pathogens

E Zankari, R Allesøe, KG Joensen… - Journal of …, 2017 - academic.oup.com
Background Antibiotic resistance is a major health problem, as drugs that were once highly
effective no longer cure bacterial infections. WGS has previously been shown to be an …

The use of next generation sequencing for improving food safety: Translation into practice

B Jagadeesan, P Gerner-Smidt, MW Allard, S Leuillet… - Food …, 2019 - Elsevier
Abstract Next Generation Sequencing (NGS) combined with powerful bioinformatic
approaches are revolutionising food microbiology. Whole genome sequencing (WGS) of …

MicroScope: an integrated platform for the annotation and exploration of microbial gene functions through genomic, pangenomic and metabolic comparative analysis

D Vallenet, A Calteau, M Dubois, P Amours… - Nucleic acids …, 2020 - academic.oup.com
Large-scale genome sequencing and the increasingly massive use of high-throughput
approaches produce a vast amount of new information that completely transforms our …

Whole-genome sequencing of bacterial pathogens: the future of nosocomial outbreak analysis

S Quainoo, JPM Coolen, SAFT van Hijum… - Clinical microbiology …, 2017 - journals.asm.org
Outbreaks of multidrug-resistant bacteria present a frequent threat to vulnerable patient
populations in hospitals around the world. Intensive care unit (ICU) patients are particularly …

[HTML][HTML] Genomics for emerging pathogen identification and monitoring: Prospects and obstacles

V Vashisht, A Vashisht, AK Mondal, J Farmaha… - …, 2023 - mdpi.com
Emerging infectious diseases (EIDs) pose an increasingly significant global burden, driven
by urbanization, population explosion, global travel, changes in human behavior, and …

Pathogenicity assessment of Shiga toxin‐producing Escherichia coli (STEC) and the public health risk posed by contamination of food with STEC

EFSA Biohaz Panel, K Koutsoumanis, A Allende… - Efsa …, 2020 - Wiley Online Library
The provisional molecular approach, proposed by EFSA in 2013, for the pathogenicity
assessment of Shiga toxin‐producing Escherichia coli (STEC) has been reviewed. Analysis …