Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Covering: 1988 to 2012 This review presents recommended nomenclature for the
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …
Conotoxins: chemistry and biology
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …
and defense, providing the basis for survival and rapid diversification of the now estimated …
Discovery, synthesis, and structure–activity relationships of conotoxins
Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena,
and they continue to attract interest due to their high potency, bioavailability, and fewer …
and they continue to attract interest due to their high potency, bioavailability, and fewer …
Introducing BASE: the Biomes of Australian Soil Environments soil microbial diversity database
Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …
Molecular phylogeny and evolution of the cone snails (Gastropoda, Conoidea)
We present a large-scale molecular phylogeny that includes 320 of the 761 recognized valid
species of the cone snails (Conus), one of the most diverse groups of marine molluscs …
species of the cone snails (Conus), one of the most diverse groups of marine molluscs …
Cone snails: A big store of conotoxins for novel drug discovery
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than
700 species, have always been one of the focuses for new drug discovery. These venomous …
700 species, have always been one of the focuses for new drug discovery. These venomous …
Conotoxin gene superfamilies
Conotoxins are the peptidic components of the venoms of marine cone snails (genus
Conus). They are remarkably diverse in terms of structure and function. Unique potency and …
Conus). They are remarkably diverse in terms of structure and function. Unique potency and …
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom
Cone snails produce highly complex venom comprising mostly small biologically active
peptides known as conotoxins or conopeptides. Early estimates that suggested 50–200 …
peptides known as conotoxins or conopeptides. Early estimates that suggested 50–200 …
Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae
Animal venoms represent a vast library of bioactive peptides and proteins with proven
potential, not only as research tools but also as drug leads and therapeutics. This is …
potential, not only as research tools but also as drug leads and therapeutics. This is …
Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks
Cone snails are predatory marine gastropods characterized by a sophisticated venom
apparatus responsible for the biosynthesis and delivery of complex mixtures of cysteine-rich …
apparatus responsible for the biosynthesis and delivery of complex mixtures of cysteine-rich …