Oxidative stress has been implicated in many chronic diseases. However, antioxidant trials
are so far largely unsuccessful as a preventive or curative measure. Chronic low‐grade …

Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

Cardiovascular diseases are the most prevalent cause of morbidity and mortality among
patients with type 1 or type 2 diabetes. The proposed mechanisms that can link accelerated …

Cancer comprises a group of heterogeneous diseases encompassing high rates of
morbidity and mortality. Heterogeneity, which is a hallmark of cancer, is one of the main …

atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …