Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects
G El-Saber Batiha, A Alqahtani, OB Ilesanmi, AA Saati… - Pharmaceuticals, 2020 - mdpi.com
Avermectins are a group of drugs that occurs naturally as a product of fermenting
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …
A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current …
P Jittamala, W Monteiro, MR Smit… - PLoS neglected …, 2021 - journals.plos.org
Background Oral ivermectin is a safe broad spectrum anthelminthic used for treating several
neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children …
neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children …
Mass drug administration of ivermectin and dihydroartemisinin–piperaquine against malaria in settings with high coverage of standard control interventions: a cluster …
ED Dabira, HM Soumare, B Conteh… - The Lancet Infectious …, 2022 - thelancet.com
Background Although the malaria burden has substantially decreased in sub-Saharan
Africa, progress has stalled. We assessed whether mass administration of ivermectin (a …
Africa, progress has stalled. We assessed whether mass administration of ivermectin (a …
Pharmacometrics of high dose ivermectin in early COVID-19: an open label, randomized, controlled adaptive platform trial (PLATCOV)
WHK Schilling, P Jittamala, JA Watson… - Elife, 2023 - elifesciences.org
Background: There is no generally accepted methodology for in vivo assessment of antiviral
activity in SARS-CoV-2 infections. Ivermectin has been recommended widely as a treatment …
activity in SARS-CoV-2 infections. Ivermectin has been recommended widely as a treatment …
Structure-switching aptamer sensors for the specific detection of piperaquine and mefloquine
Tracking antimalarial drug use and efficacy is essential for monitoring the current spread of
antimalarial drug resistance. However, available methods for determining tablet quality and …
antimalarial drug resistance. However, available methods for determining tablet quality and …
Ivermectin as a novel complementary malaria control tool to reduce incidence and prevalence: a modelling study
Background Ivermectin is a potential new vector control tool to reduce malaria transmission.
Mosquitoes feeding on a bloodmeal containing ivermectin have a reduced lifespan …
Mosquitoes feeding on a bloodmeal containing ivermectin have a reduced lifespan …
Applying the COM-B behaviour change model to a pilot study delivering volatile pyrethroid spatial repellents and insecticide-treated clothing to forest-exposed …
I Chen, D Doum, K Mannion, J Hustedt, S Sovannaroth… - Malaria Journal, 2023 - Springer
Abstract Background Southeast Asia is making tremendous progress towards their 2030
malaria elimination goal but needs new interventions to stop forest malaria. This study trials …
malaria elimination goal but needs new interventions to stop forest malaria. This study trials …
Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes
Abstract Background Ivermectin (22, 23-dihydroavermectin B1a: H2B1a) is an endectocide
used to treat worm infections and ectoparasites including lice and scabies mites …
used to treat worm infections and ectoparasites including lice and scabies mites …
Adjunctive ivermectin mass drug administration for malaria control on the Bijagos Archipelago of Guinea-Bissau (MATAMAL): a quadruple-blinded, cluster …
H Hutchins, E Pretorius, J Bradley… - The Lancet Infectious …, 2024 - thelancet.com
Background Arthropod vectors feeding on the blood of individuals treated with ivermectin
have substantially increased mortality. Whether this effect will translate into a useful tool for …
have substantially increased mortality. Whether this effect will translate into a useful tool for …
Ivermectin: a promising therapeutic for fighting malaria. Current status and perspective
Finding new chemotherapeutic interventions to treat malaria through repurposing of time-
tested drugs and rigorous design of new drugs using tools of rational drug design remains …
tested drugs and rigorous design of new drugs using tools of rational drug design remains …