Nano-LC in proteomics: recent advances and approaches
In proteomics, nano-LC is arguably the most common tool for separating peptides/proteins
prior to MS. The main advantage of nano-LC is enhanced sensitivity, as compounds enter …
prior to MS. The main advantage of nano-LC is enhanced sensitivity, as compounds enter …
High-quality and robust protein quantification in large clinical/pharmaceutical cohorts with IonStar proteomics investigation
Robust, reliable quantification of large sample cohorts is often essential for meaningful
clinical or pharmaceutical proteomics investigations, but it is technically challenging. When …
clinical or pharmaceutical proteomics investigations, but it is technically challenging. When …
IonStar enables high-precision, low-missing-data proteomics quantification in large biological cohorts
Reproducible quantification of large biological cohorts is critical for clinical/pharmaceutical
proteomics yet remains challenging because most prevalent methods suffer from drastically …
proteomics yet remains challenging because most prevalent methods suffer from drastically …
An IonStar experimental strategy for MS1 ion current-based quantification using ultrahigh-field orbitrap: reproducible, in-depth, and accurate protein measurement in …
In-depth and reproducible protein measurement in many biological samples is often critical
for pharmaceutical/biomedical proteomics but remains challenging. MS1-based …
for pharmaceutical/biomedical proteomics but remains challenging. MS1-based …
MS1 ion current‐based quantitative proteomics: A promising solution for reliable analysis of large biological cohorts
The rapidly‐advancing field of pharmaceutical and clinical research calls for systematic,
molecular‐level characterization of complex biological systems. To this end, quantitative …
molecular‐level characterization of complex biological systems. To this end, quantitative …
Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry
A major goal in signaling biology is the establishment of high-throughput quantitative
methods for measuring changes in protein phosphorylation of entire signal transduction …
methods for measuring changes in protein phosphorylation of entire signal transduction …
A novel PDE4D inhibitor BPN14770 reverses scopolamine-induced cognitive deficits via cAMP/SIRT1/Akt/Bcl-2 pathway
Y Wang, S Gao, V Zheng, L Chen, M Ma… - Frontiers in cell and …, 2020 - frontiersin.org
A global, quantitative proteomics/systems-biology analysis of the selective pharmacological
inhibition of phosphodiesterase-4D (PDE4D) revealed the differential regulation of pathways …
inhibition of phosphodiesterase-4D (PDE4D) revealed the differential regulation of pathways …
Surfactant-aided precipitation/on-pellet-digestion (SOD) procedure provides robust and rapid sample preparation for reproducible, accurate and sensitive LC/MS …
For targeted protein quantification by liquid chromatography mass spectrometry (LC/MS), an
optimal approach for efficient, robust and hi-throughput sample preparation is critical, but …
optimal approach for efficient, robust and hi-throughput sample preparation is critical, but …
Surfactant cocktail-aided extraction/precipitation/on-pellet digestion strategy enables efficient and reproducible sample preparation for large-scale quantitative …
For quantitative proteomics, efficient, robust, and reproducible sample preparation with high
throughput is critical yet challenging, especially when large cohorts are involved, as is often …
throughput is critical yet challenging, especially when large cohorts are involved, as is often …
Transitioning from basic toward systems pharmacodynamic models: lessons from corticosteroids
Technology in bioanalysis,-omics, and computation have evolved over the past half century
to allow for comprehensive assessments of the molecular to whole body pharmacology of …
to allow for comprehensive assessments of the molecular to whole body pharmacology of …