The extracellular matrix (ECM) plays an important role in cancer progression. It can be
divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Recent studies have shown that the tumor extracellular matrix (ECM) associates with
immunosuppression, and that targeting the ECM can improve immune infiltration and …

The tumor microenvironment (TME) is composed of various cell types embedded in an
altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also …

The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Metastasis or the progression of malignancy poses a major challenge in cancer therapy and
is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) …

Risk factors for pancreatic ductal adenocarcinoma (PDAC) progression after surgery are
unclear, and additional prognostic factors are needed to inform treatment regimens and …

Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between
tumor cells and the stroma to promote tumor progression. Consequently, strategies to target …

Liquid biopsy is a convenient, fast, non-invasive and reproducible sampling method that can
dynamically reflect the changes in tumor gene expression profile, and provide a robust basis …

The extracellular matrix (ECM) is a meshwork of proteins and carbohydrates that supports
many biological structures and processes, from tissue development and elasticity to …