Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa

CV Pulford, BM Perez-Sepulveda, R Canals… - Nature …, 2021 - nature.com
Bloodstream infections caused by nontyphoidal Salmonella are a major public health
concern in Africa, causing~ 49,600 deaths every year. The most common Salmonella …

[HTML][HTML] Decoding the invasive nature of a tropical pathogen of concern: The invasive non-Typhoidal Salmonella strains causing host-restricted extraintestinal …

D Hajra, AV Nair, D Chakravortty - Microbiological Research, 2023 - Elsevier
Abstract Invasive-Non-Typhoidal Salmonella (iNTS) are the major cause of health concern
in the low-income, under-developed nations in Africa and Asia that lack proper sanitation …

[HTML][HTML] Prophages encode phage-defense systems with cognate self-immunity

SV Owen, N Wenner, CL Dulberger, EV Rodwell… - Cell host & …, 2021 - cell.com
Temperate phages are pervasive in bacterial genomes, existing as vertically inherited
islands termed prophages. Prophages are vulnerable to predation of their host bacterium by …

Pathogenic signature of invasive non-typhoidal Salmonella in Africa: implications for vaccine development

G Piccini, E Montomoli - Human vaccines & immunotherapeutics, 2020 - Taylor & Francis
Invasive non-typhoidal Salmonella (iNTS) infections are a leading cause of bacteremia in
Sub-Saharan Africa (sSA), thereby representing a major public health threat. Salmonella …

Decoding the stoichiometric composition and organisation of bacterial metabolosomes

M Yang, DM Simpson, N Wenner, P Brownridge… - Nature …, 2020 - nature.com
Some enteric bacteria including Salmonella have evolved the propanediol-utilising
microcompartment (Pdu MCP), a specialised proteinaceous organelle that is essential for 1 …

A window into lysogeny: revealing temperate phage biology with transcriptomics

SV Owen, R Canals, N Wenner… - Microbial …, 2020 - microbiologyresearch.org
Prophages are integrated phage elements that are a pervasive feature of bacterial
genomes. The fitness of bacteria is enhanced by prophages that confer beneficial functions …

Whole genome sequencing of Salmonella enterica serovars isolated from humans, animals, and the environment in Lagos, Nigeria

KO Akinyemi, CO Fakorede, J Linde, U Methner… - Bmc Microbiology, 2023 - Springer
Background Salmonella infections remain an important public health issue worldwide. Some
serovars of non-typhoidal Salmonella (NTS) have been associated with bloodstream …

Global discovery of bacterial RNA-binding proteins by RNase-sensitive gradient profiles reports a new FinO domain protein

M Gerovac, Y El Mouali, J Kuper, C Kisker, L Barquist… - Rna, 2020 - rnajournal.cshlp.org
RNA-binding proteins (RBPs) play important roles in bacterial gene expression and
physiology but their true number and functional scope remain little understood even in …

The genetic basis of phage susceptibility, cross-resistance and host-range in Salmonella

BA Adler, AE Kazakov, C Zhong, H Liu… - …, 2021 - microbiologyresearch.org
Though bacteriophages (phages) are known to play a crucial role in bacterial fitness and
virulence, our knowledge about the genetic basis of their interaction, cross-resistance and …

Targeting two-component systems uncovers a small-molecule inhibitor of Salmonella virulence

CN Tsai, CR MacNair, MPT Cao, JN Perry… - Cell chemical …, 2020 - cell.com
Salmonella serovars are leading causes of gastrointestinal disease and have become
increasingly resistant to fluoroquinolone and cephalosporin antibiotics. Overcoming this …