Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

Conspectus The field of gene therapy, which aims to treat patients by modulating gene
expression, has come to fruition and has landed several landmark FDA approvals. Most …

Combination therapy is an emerging strategy that is under intensive preclinical investigation
for the treatment of various diseases. CD98 is highly overexpressed on the surfaces of …

Gold colloids functionalized with amino acids provide a scaffold for effective DNA binding
with subsequent condensation. Particles with lysine and lysine dendron functionality formed …

Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased
cells. However, its widespread clinical use has faltered in the face of several challenges …

Overcoming adverse effects and selectively delivering drug to target cells are two major
challenges in the treatment of ulcerative colitis (UC). Lysine-proline-valine (KPV), a naturally …

Background & Aims Nanoparticles have been explored as carriers of small interfering RNAs
(siRNAs) and might be developed to treat patients with inflammatory bowel disease (IBD) …

Pro-resolving factors that are critical for colonic epithelial restitution were down-regulated
during the treatment with inhibitor of pro-inflammatory cytokines (eg, anti-TNFα antibody) in …

Nanoparticle (NP)-based combination chemotherapy has been proposed as an effective
strategy for achieving synergistic effects and targeted drug delivery for colon cancer therapy …

Nanoparticle (NP)-based combination chemotherapy has been proposed as a potent
strategy for enhancing intracellular drug concentrations and achieving synergistic effects in …