The role of the liver-specific microRNA, miRNA-122 in the HCV replication cycle
RD Kunden, JQ Khan, S Ghezelbash… - International Journal of …, 2020 - mdpi.com
Hepatitis C virus (HCV) replication requires annealing of a liver specific microRNA, miR-122
to 2 sites on 5′ untranslated region (UTR). While, microRNAs downregulate gene …
to 2 sites on 5′ untranslated region (UTR). While, microRNAs downregulate gene …
[HTML][HTML] MicroRNAs and HIV-1 infection: antiviral activities and beyond
Cellular microRNAs (miRNAs) are an important class of small, non-coding RNAs that bind to
host mRNAs based on sequence complementarity and regulate protein expression. They …
host mRNAs based on sequence complementarity and regulate protein expression. They …
miR-122 stimulates hepatitis C virus RNA synthesis by altering the balance of viral RNAs engaged in replication versus translation
The liver-specific microRNA, miR-122, stabilizes hepatitis C virus (HCV) RNA genomes by
recruiting host argonaute 2 (AGO2) to the 5′ end and preventing decay mediated by …
recruiting host argonaute 2 (AGO2) to the 5′ end and preventing decay mediated by …
Regulation of hepatitis C virus genome replication by Xrn1 and microRNA-122 binding to individual sites in the 5′ untranslated region
ABSTRACT miR-122 is a liver-specific microRNA (miRNA) that binds to two sites (S1 and
S2) on the 5′ untranslated region (UTR) of the hepatitis C virus (HCV) genome and …
S2) on the 5′ untranslated region (UTR) of the hepatitis C virus (HCV) genome and …
Elucidating the distinct contributions of miR-122 in the HCV life cycle reveals insights into virion assembly
M Rheault, SE Cousineau, DR Fox… - Nucleic acids …, 2023 - academic.oup.com
Efficient hepatitis C virus (HCV) RNA accumulation is dependent upon interactions with the
human liver-specific microRNA, miR-122. MiR-122 has at least three roles in the HCV life …
human liver-specific microRNA, miR-122. MiR-122 has at least three roles in the HCV life …
XRN1 stalling in the 5'UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability
We demonstrate that both Hepatitis C virus (HCV) and Bovine Viral Diarrhea virus (BVDV)
contain regions in their 5'UTRs that stall and repress the enzymatic activity of the cellular 5' …
contain regions in their 5'UTRs that stall and repress the enzymatic activity of the cellular 5' …
The emerging role of miRNA-122 in infectious diseases: Mechanisms and potential biomarkers
R Mirzaei, S Karampoor, NL Korotkova - Pathology-Research and Practice, 2023 - Elsevier
Abstract microRNAs (miRNAs) are small, non-coding RNA molecules that play crucial
regulatory roles in numerous cellular processes. Recent investigations have highlighted the …
regulatory roles in numerous cellular processes. Recent investigations have highlighted the …
Dissecting noncoding and pathogen RNA–protein interactomes
RNA–protein interactions are central to biological regulation. Cross-linking
immunoprecipitation (CLIP)-seq is a powerful tool for genome-wide interrogation of RNA …
immunoprecipitation (CLIP)-seq is a powerful tool for genome-wide interrogation of RNA …
Signals involved in regulation of hepatitis C virus RNA genome translation and replication
M Niepmann, LA Shalamova, GK Gerresheim… - Frontiers in …, 2018 - frontiersin.org
Hepatitis C virus (HCV) preferentially replicates in the human liver and frequently causes
chronic infection, often leading to cirrhosis and liver cancer. HCV is an enveloped virus …
chronic infection, often leading to cirrhosis and liver cancer. HCV is an enveloped virus …
[HTML][HTML] Role of ROCK signaling in virus replication
Rho-associated protein kinase (ROCK) is a serine-threonine kinase and is a major
downstream effector of the small GTPaseRhoA. Upon activation, Rho/ROCK cell signaling …
downstream effector of the small GTPaseRhoA. Upon activation, Rho/ROCK cell signaling …