Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation
The process of neurodegeneration in Parkinson's Disease is intimately associated with the
aggregation of the protein α-synuclein into toxic oligomers and fibrils. Interestingly, many of …
aggregation of the protein α-synuclein into toxic oligomers and fibrils. Interestingly, many of …
Native chemical ligation of thioamide-containing peptides: development and application to the synthesis of labeled α-synuclein for misfolding studies
S Batjargal, YJ Wang, JM Goldberg… - Journal of the …, 2012 - ACS Publications
Thioamide modifications of the peptide backbone are used to perturb secondary structure, to
inhibit proteolysis, as photoswitches, and as spectroscopic labels. Thus far, their …
inhibit proteolysis, as photoswitches, and as spectroscopic labels. Thus far, their …
Crocin inhibits the fibrillation of human α-synuclein and disassembles mature fibrils: experimental findings and mechanistic insights from molecular dynamics …
B Saffari, M Amininasab - ACS Chemical Neuroscience, 2021 - ACS Publications
The aggregation of human alpha-synuclein (hαS) is pivotally implicated in the development
of most types of synucleinopathies. Molecules that can inhibit or reverse the aggregation …
of most types of synucleinopathies. Molecules that can inhibit or reverse the aggregation …
Modification of C terminus provides new insights into the mechanism of α-synuclein aggregation
Aggregation of neuronal protein α-synuclein leads to the formation of amyloid fibrils, which
are associated with the development of Parkinson's disease. The mechanism of α-synuclein …
are associated with the development of Parkinson's disease. The mechanism of α-synuclein …