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Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions
The notion that all protein functions are determined through macromolecular interactions is
the driving force behind current efforts that aim to solve the structures of all cellular …
the driving force behind current efforts that aim to solve the structures of all cellular …
Predicting protein function from sequence and structure
While the number of sequenced genomes continues to grow, experimentally verified
functional annotation of whole genomes remains patchy. Structural genomics projects are …
functional annotation of whole genomes remains patchy. Structural genomics projects are …
Contacts-based prediction of binding affinity in protein–protein complexes
Almost all critical functions in cells rely on specific protein–protein interactions.
Understanding these is therefore crucial in the investigation of biological systems. Despite …
Understanding these is therefore crucial in the investigation of biological systems. Despite …
Interactome3D: adding structural details to protein networks
Network-centered approaches are increasingly used to understand the fundamentals of
biology. However, the molecular details contained in the interaction networks, often …
biology. However, the molecular details contained in the interaction networks, often …
FireDock: a web server for fast interaction refinement in molecular docking
Structural details of protein–protein interactions are invaluable for understanding and
deciphering biological mechanisms. Computational docking methods aim to predict the …
deciphering biological mechanisms. Computational docking methods aim to predict the …
Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry
The identification of proximate amino acids by chemical cross-linking and mass
spectrometry (XL-MS) facilitates the structural analysis of homogeneous protein complexes …
spectrometry (XL-MS) facilitates the structural analysis of homogeneous protein complexes …
Transient protein–protein interactions
Transient complexes are crucial for diverse biological processes such as biochemical
pathways and signaling cascades in the cell. Here, we give an overview of the transient …
pathways and signaling cascades in the cell. Here, we give an overview of the transient …
Protein–protein interactions: detection, reliability assessment and applications
Protein–protein interactions (PPIs) participate in all important biological processes in living
organisms, such as catalyzing metabolic reactions, DNA replication, DNA transcription …
organisms, such as catalyzing metabolic reactions, DNA replication, DNA transcription …
Relating three-dimensional structures to protein networks provides evolutionary insights
Most studies of protein networks operate on a high level of abstraction, neglecting structural
and chemical aspects of each interaction. Here, we characterize interactions by using atomic …
and chemical aspects of each interaction. Here, we characterize interactions by using atomic …
Recent progress and future directions in protein-protein docking
This article gives an overview of recent progress in protein-protein docking and it identifies
several directions for future research. Recent results from the CAPRI blind docking …
several directions for future research. Recent results from the CAPRI blind docking …