Reactive oxygen species (ROS) play an essential role in physiological and pathological
processes. Studies on the regulation of ROS for disease treatments have caused wide …

The blood–spinal cord barrier (BSCB) is the functional equivalent of the blood–brain barrier
(BBB) in the sense of providing a specialized microenvironment for the cellular constituents …

Immobilized enzyme-based catalytic constructs could greatly improve various industrial
processes due to their extraordinary catalytic activity and reaction specificity. In recent …

Stroke is one of the major causes of death and disability in the United States. After cerebral
ischemia and reperfusion injury, the generation of reactive oxygen species (ROS) and …

A variety of therapeutic proteins have shown potential to treat central nervous system (CNS)
disorders. Challenge to deliver these protein molecules to the brain is well known. Proteins …

Interactions of nanoparticles with biological matter—both somatically and in nature—draw
scientists' attention. Nanoparticulate systems are believed to be our saviors, acting as …

The increasing incidence of diseases affecting the central nervous system (CNS) demands
the urgent development of efficient drugs. While many of these medicines are already …

Spinal cord injury results in significant mortality and morbidity, lifestyle changes, and difficult
rehabilitation. Treatment of spinal cord injury is challenging because the spinal cord is both …

Superoxide dismutase 1 (SOD1) efficiently catalyzes dismutation of superoxide, but its poor
delivery to the target sites in the body, such as brain, hinders its use as a therapeutic agent …

P-glycoprotein (Pgp) overexpression in the blood brain barrier (BBB) is hypothesized to
lower brain drug concentrations and thus inhibit anticonvulsant effects in drug-resistant …