Higher eukaryotic development is a complex and tightly regulated process, whereby
transcription factors (TFs) play a key role in controlling the gene regulatory networks …

In humans, specific aberrations in β-globin results in sickle cell disease and β-thalassemia,
symptoms of which can be ameliorated by increased expression of fetal globin (HbF). Two …

The CCCTC-binding factor (CTCF) binds tens of thousands of enhancers and promoters on
mammalian chromosomes by means of its 11 tandem zinc finger (ZF) DNA-binding domain …

Summary Cys2-His2 zinc-finger proteins (C2H2-ZNFs) constitute the largest class of DNA-
binding transcription factors (TFs) yet remain largely uncharacterized. Although certain …

Objective Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial roles
in hepatocellular carcinoma (HCC). A rapidly increasing number of studies have shown that …

Genomic regions with high guanine content can fold into non-B form DNA four-stranded
structures known as G-quadruplexes (G4s). Extensive in vivo investigations have revealed …

Non-alcoholic fatty liver disease (NAFLD) is a burgeoning global public health distress, with
an estimated 25% of the world population affected. Despite the increasing prevalence and …

Aims The isocitrate dehydrogenase (IDH) phenotype is associated with reprogrammed
energy metabolism in glioblastoma (GBM) cells. Small nucleolar RNAs (snoRNAs) are …

Glioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor
prognosis. Although patients with GBM are treated with surgery, chemotherapy, and …

ZBTB7A belongs to a small family of transcription factors having three members in humans
(7A, 7B, and 7C). They share a BTB/POZ protein interaction domain at the amino end and a …