A major feature of Alzheimer's disease (AD) pathology is the plaque composed of
aggregated amyloid-β (Aβ) peptide. Although these plaques may have harmful properties …

The purpose of our article is to assess the current understanding of Indian spice, curcumin,
against amyloid-β (Aβ)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Objective: To examine the relationship between alcohol, both the amount and type, and
cognitive decline in a cohort of Alzheimer's disease (AD) patients. Methods: A cohort of 360 …

Although Alzheimer's disease (AD) characterized with senile plaques and neurofibrillary
tangles has been found for over 100 years, its molecular mechanisms are ambiguous. More …

Background Less than half of patients with major depressive disorder (MDD) respond to
their first antidepressant trial. Our understanding of the underlying mechanisms of selective …

Posttraumatic stress disorder (PTSD) is associated with impaired major domains of
psychology and behavior. Individuals with PTSD also have increased co-morbidity with …

Aims β-Amyloid (Aβ)-mediated neurotoxicity plays a critical role in the pathogenesis of
Alzheimer's disease (AD), possibly including Aβ-induced mitochondrial dysfunction and …

Abstract A number of N-(2-(1H-indol-3-yl) ethyl)-2-oxo-2H-chromene-3-carboxamides were
synthesized and tested against AChE and BuChE. The in vitro assessment of the …

Cyclophilin D (CypD) is a peptidyl prolyl isomerase F that resides in the mitochondrial matrix
and associates with the inner mitochondrial membrane during the mitochondrial membrane …