[HTML][HTML] Genetics and molecular pathogenesis of gastric adenocarcinoma

P Tan, KG Yeoh - Gastroenterology, 2015 - Elsevier
Gastric cancer (GC) is globally the fifth most common cancer and third leading cause of
cancer death. A complex disease arising from the interaction of environmental and host …

Mast cells, angiogenesis and lymphangiogenesis in human gastric cancer

G Sammarco, G Varricchi, V Ferraro… - International journal of …, 2019 - mdpi.com
Gastric cancer is diagnosed in nearly one million new patients each year and it remains the
second leading cause of cancer-related deaths worldwide. Although gastric cancer …

[HTML][HTML] Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression

R Wang, S Song, J Qin, K Yoshimura, F Peng, Y Chu… - Cancer Cell, 2023 - cell.com
Understanding tumor microenvironment (TME) reprogramming in gastric adenocarcinoma
(GAC) progression may uncover novel therapeutic targets. Here, we performed single-cell …

LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc

J Tang, T Yan, Y Bao, C Shen, C Yu, X Zhu… - Nature …, 2019 - nature.com
Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role
of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In …

LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway

XZ Yang, TT Cheng, QJ He, ZY Lei, J Chi, Z Tang… - Molecular cancer, 2018 - Springer
Background Gastric cancer (GC) is a common malignancy and frequent cause of cancer-
related death. Long non-coding RNAs (lncRNAs) have emerged as important regulators and …

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

R Cristescu, J Lee, M Nebozhyn, KM Kim, JC Ting… - Nature medicine, 2015 - nature.com
Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We
aim to establish clinically relevant molecular subtypes that would encompass this …

LncRNA PVT1 promotes angiogenesis via activating the STAT3/VEGFA axis in gastric cancer

J Zhao, P Du, P Cui, Y Qin, C Hu, J Wu, Z Zhou… - Oncogene, 2018 - nature.com
Angiogenesis can aggravate gastric cancer progression. LncRNAs exert important roles in
regulating various cancer behaviors. However, the functions and mechanisms of lncRNAs in …

LncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern

TT Sun, J He, Q Liang, LL Ren, TT Yan, TC Yu… - Cancer …, 2016 - aacrjournals.org
Long noncoding RNAs (lncRNA) play a role in carcinogenesis. However, the function of
lncRNAs in human gastric cancer remains largely unknown. In this study, we identified a …

Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma

R Wang, M Dang, K Harada, G Han, F Wang… - Nature medicine, 2021 - nature.com
Intratumoral heterogeneity (ITH) is a fundamental property of cancer; however, the origins of
ITH remain poorly understood. We performed single-cell transcriptome profiling of peritoneal …

Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

MA Chiurillo - World journal of experimental medicine, 2015 - pmc.ncbi.nlm.nih.gov
Gastric cancer remains one of the most common cancers worldwide and one of the leading
cause for cancer-related deaths. Gastric adenocarcinoma is a multifactorial disease that is …