Hodgkin lymphoma is considered a prime example of treatment success, with cure rates
exceeding 80% using modern combined modality therapies. However, especially in …

Noninvasive monitoring of minimal residual disease (MRD) has led to significant advances
in personalized management of patients with hematologic malignancies. Improved …

The rarity of neoplastic cells in the biopsy imposes major technical hurdles that have so far
limited genomic studies in classical Hodgkin lymphoma (cHL). By using a highly sensitive …

We used hybrid capture-targeted next-generation sequencing of circulating cell-free DNA
(ccfDNA) of pediatric Hodgkin lymphoma (PHL) patients to determine pathogenic …

The clearance of malignant clonal cells significantly correlates with clinical outcomes in
many hematologic malignancies. Accurate and high throughput tools for minimal residual …

The advent of new technologies such as massive parallel sequencing has improved our
understanding of the genetics of classical Hodgkin lymphoma. Some of these discoveries …

Pathogenic viruses have evolved to manipulate the host cell utilising a variety of strategies
including expression of viral proteins to hijack or mimic the activity of cellular functions. DNA …

Abstract The malignant Hodgkin and Reed Sternberg (HRS) cells of classical Hodgkin
lymphoma (cHL) are scarce in affected lymph nodes, creating a challenge to detect driver …

Introducción: El linfoma de Hodgkin clásico presenta escasas células de Reed
Sternberg/Hodgkin inmersas en un abundante microambiente tumoral. Los desbalances …

The clearance of cancer cells is closely associated with the prognosis of various
hematologic malignancies. Clinical studies have shown that minimal residual disease …