The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

Without any exaggeration, cholesterol is one of the most important lipid species in eukaryotic
cells. Its effects on cellular membranes and functions range from purely mechanistic to …

The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

Menopause results in a progressive decline in 17β-estradiol (E2) levels, increased
adiposity, decreased insulin sensitivity, and a higher risk for type 2 diabetes. Estrogen …

Abstract Background Membrane proteins (MPs) play diverse and important functions in
living organisms. They constitute 20% to 30% of the known bacterial, archaean and …

This paper reviews various enhanced conformational sampling methods and explicit/implicit
solvent/membrane models, as well as their recent applications to the exploration of the …

In women, ovary and adrenal gland produce androgens. Androgens are essential drivers of
the primordial to antral follicle development, prior to serving as substrate for estrogen …

Steroid hormones are a large family of cholesterol derivatives regulating development and
physiology in both the animal and plant kingdoms, but little is known concerning …

Cereals, which belong to the Poaceae family, are the most economically important group of
plants. Among abiotic stresses, temperature stresses are a serious and at the same time …

In addition to the classic genomic mechanism of steroid action mediated by activation of
intracellular nuclear receptors, there is now extensive evidence that steroids also activate …