Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …

Abstract NAD (P) H-dependent oxidoreductases catalyze the reduction or oxidation of a
substrate coupled to the oxidation or reduction, respectively, of a nicotinamide adenine …

The use of engineered ketoreductases (KREDS), both as whole microbial cells and isolated
enzymes, in the highly enantiospecific reduction of prochiral ketones is reviewed. The …

A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of configurationally
labile N-arylindole aldehydes is described. The DKR proceeds by atroposelective …

Many successful stories in enzyme engineering are based on the creation of randomized
diversity in large mutant libraries, containing millions to billions of enzyme variants. Methods …

The quest for sustainable solvents is currently a matter of intense research and
development, as solvents significantly contribute heavily to the waste generated by chemical …

Hydrogenation reactions in biology are usually carried out by enzymes with nicotinamide
adenine dinucleotide (NAD (P) H) or flavin mononucleotide (FAMH2)/flavinadenine …

The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical
fields are interconnected and synergized. A way to depict that innovation is by conducting a …

Biocatalysis has become an important component of modern organic chemistry, presenting
an efficient and environmentally friendly approach to synthetic transformations. Advances in …