Viruses of archaea represent one of the most enigmatic parts of the virosphere. Most of the
characterized archaeal viruses infect extremophilic hosts and display remarkable diversity of …

One of the most prominent features of archaea is the extraordinary diversity of their DNA
viruses. Many archaeal viruses differ substantially in morphology from bacterial and …

Herpesviruses assemble large enveloped particles that are difficult to characterize
structurally due to their size, fragility and complex multilayered proteome with partially …

Herpesviruses are enveloped viruses that are prevalent in the human population and are
responsible for diverse pathologies, including cold sores, birth defects and cancers. They …

INTRODUCTION Since Hippocrates first described the cutaneous spreading of herpes
simplex lesions, many other diseases—chickenpox, infectious mononucleosis …

Although viruses are extremely diverse in shape and size, evolution has led to a limited
number of viral classes or lineages, which is probably linked to the assembly constraints of a …

The compartmentalization of eukaryotic cells presents considerable challenges to the
herpesvirus life cycle. The herpesvirus tegument, a bulky proteinaceous aggregate …

Viruses have evolved protein containers with a wide spectrum of icosahedral architectures
to protect their genetic material. The geometric constraints defining these container designs …

INTRODUCTION Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus and is
the leading causative agent of genital ulcer disease (GUD) worldwide. Patients with HSV-2 …

The Ewald sphere effect is generally neglected when using the Central Projection Theorem
for cryo electron microscopy single-particle reconstructions. This can reduce the resolution …