Benign breast disease (BBD) is a broad category of diagnoses reported to convey a variable
degree of increased risk of develo** breast cancer. A meta-analysis of the existing …

Breast cancers with positive expression of Estrogen Receptor (ER+) are treated with anti-
hormone/endocrine therapy which targets the activity of the receptor, the half-life of the …

Deaths from breast cancer have fallen markedly over the past decade due, in part, to the use
of endocrine agents that reduce the levels of circulating oestrogens or compete with …

Background The long time from exposure to potentially harmful chemicals until breast
cancer occurrence poses challenges for designing etiologic studies and for implementing …

Endocrine therapy has become one of most effective forms of targeted adjuvant therapy for
hormone-sensitive breast cancer and may be given after surgery or radiotherapy, and also …

Estrogens have long been recognized as being important for stimulating the growth of a
large proportion of breast cancers. Now it is recognized that estrogen action is mediated by …

Abstract Using an Affymetrix 10K SNP array to screen for gene copy number changes in
breast cancer, we detected a single-gene amplification of the ESR1 gene, which encodes …

Most human invasive breast cancers (IBCs) appear to develop over long periods of time
from certain pre-existing benign lesions. Of the many types of benign lesions in the human …

To understand the significance of estrogen receptor β (ERβ) in mammary carcinogenesis,
we evaluated the expression of ERβ in preinvasive mammary tumors. The percentage of …

Estrogens play an important role in regulating the growth and differentiation of normal,
premalignant and malignant cell types, especially breast epithelial cells, through interaction …