The effective size of a population, N e, determines the rate of change in the composition of a
population caused by genetic drift, which is the random sampling of genetic variants in a …

Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …

The identification of signals of very recent positive selection provides information about the
adaptation of modern humans to local conditions. We report here on a genome-wide scan …

Demographic models built from genetic data play important roles in illuminating prehistorical
events and serving as null models in genome scans for selection. We introduce an inference …

Farming and sedentism first appeared in southwestern Asia during the early Holocene and
later spread to neighboring regions, including Europe, along multiple dispersal routes …

There has long been interest in understanding the genetic basis of human adaptation. To
what extent are phenotypic differences among human populations driven by natural …

Many recent statistical applications involve inference under complex models, where it is
computationally prohibitive to calculate likelihoods but possible to simulate data …

Loci involved in local adaptation can potentially be identified by an unusual correlation
between allele frequencies and important ecological variables or by extreme allele …

Whole-genome sequences provide a rich source of information about human evolution.
Here we describe an effort to estimate key evolutionary parameters based on the whole …

Genetic and paleoanthropological evidence is in accord that today's human population is
the result of a great demic (demographic and geographic) expansion that began …