[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

M Fedele, R Piersanti, F Regazzoni, M Salvador… - Computer Methods in …, 2023 - Elsevier
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

Interfacing finite elements with deep neural operators for fast multiscale modeling of mechanics problems

M Yin, E Zhang, Y Yu, GE Karniadakis - Computer methods in applied …, 2022 - Elsevier
Multiscale modeling is an effective approach for investigating multiphysics systems with
largely disparate size features, where models with different resolutions or heterogeneous …

[HTML][HTML] Multi-fidelity regression using artificial neural networks: Efficient approximation of parameter-dependent output quantities

M Guo, A Manzoni, M Amendt, P Conti… - Computer methods in …, 2022 - Elsevier
Highly accurate numerical or physical experiments are often very time-consuming or
expensive to obtain. When time or budget restrictions prohibit the generation of additional …

Active force generation in cardiac muscle cells: mathematical modeling and numerical simulation of the actin-myosin interaction

F Regazzoni, L Dedè, A Quarteroni - Vietnam Journal of Mathematics, 2021 - Springer
Cardiac in silico numerical simulations are based on mathematical models describing the
physical processes involved in the heart function. In this review paper, we critically survey …

[HTML][HTML] A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

F Regazzoni, M Salvador, PC Africa, M Fedele… - Journal of …, 2022 - Elsevier
We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …

Simulating impaired left ventricular–arterial coupling in aging and disease: a systematic review

CCA Ding, S Dokos, AA Bakir, NJ Zamberi… - BioMedical Engineering …, 2024 - Springer
Aortic stenosis, hypertension, and left ventricular hypertrophy often coexist in the elderly,
causing a detrimental mismatch in coupling between the heart and vasculature known as …

[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

A Zingaro, M Bucelli, R Piersanti, F Regazzoni… - Journal of …, 2024 - Elsevier
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics

R Piersanti, F Regazzoni, M Salvador, AF Corno… - Computer Methods in …, 2022 - Elsevier
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …

[HTML][HTML] A machine learning method for real-time numerical simulations of cardiac electromechanics

F Regazzoni, M Salvador, L Dede… - Computer methods in …, 2022 - Elsevier
We propose a machine learning-based method to build a system of differential equations
that approximates the dynamics of 3D electromechanical models for the human heart …

A geometric multiscale model for the numerical simulation of blood flow in the human left heart

A Zingaro, I Fumagalli, L Dede, M Fedele… - arxiv preprint arxiv …, 2021 - arxiv.org
We present a new computational model for the numerical simulation of blood flow in the
human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian …