Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the
homeostatic control of almost all biological processes. Their direct mode of ligand regulation …

ABSTRACT Introduction Liver X receptors (LXRs) are master regulators of atherogenesis.
Their anti-atherogenic potential has been attributed to their role in the inhibition of …

The glucocorticoid receptor (GR) is phosphorylated at multiple sites within its N terminus
(S203, S211, S226), yet the role of phosphorylation in receptor function is not understood …

Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-
related diseases. In addition, natural products are an interesting pool of potential ligands …

Cholesterol is a critical component of cell membranes, and cellular cholesterol levels and
distribution are tightly regulated in mammals. Recent evidence has revealed a critical role …

The innate immune system is the first line of defense specialized in the clearing of invaders
whether foreign elements like microbes or self-elements that accumulate abnormally …

The main contributions of our group during the last 15 years develo** and using
biomolecular simulation tools in drug lead discovery and design, in close collaboration with …

Liver X receptor α (LXRα; also known as NR1H3), an isoform of LXRs, is a member of the
nuclear receptor family of transcription factors and plays essential roles in the transcriptional …

The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor family of
transcription factors that play essential roles in the transcriptional control of lipid metabolism …

Wilson disease (WD) is a hepatoneurological disorder caused by mutations in the copper‐
transporter, ATP7B. Copper accumulation in the liver is a hallmark of WD. Current therapy is …